Reaktion #77857

Reaktionsgleichung

N-bromosuccimide

3,4-dihydro-2H-pyran

acetic acid

→

2-acetoxy-3-bromo-tetrahydropyran

Ausbeute 73.0%

Lösungsmittel

diethyl ether

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschenwashed with 50 ml of water three times
2. 2
   WaschenThe organic layer was washed with 1N NaHCO3 solution
3. 3
   Sonstigedried
4. 4
   Einengenconcentrated under a reduced pressure

Vorschrift

To the solution of N-bromosuccimide (4.5 g ) in acetic acid (14.5 ml), was added dropwise 2.3 ml of 3,4-dihydro-2H-pyran at 10° C. The reaction mixture was diluted with 50 ml of diethyl ether and washed with 50 ml of water three times. The organic layer was washed with 1N NaHCO3 solution, dried, and then concentrated under a reduced pressure to give 4.1 g of 2-acetoxy-3-bromo-tetrahydropyran as a colorless oil (yield: 73%).

Quelle