Reaktion #77845

Reaktionsgleichung

2,5-dibromopyridine

N-acetyl-propargylamine

water

→

2-1

N-(3-{5-[3-(acetamido)prop-1-ynyl]pyridin-2-yl}prop-2-ynyl)acetamide

Lösungsmittel

diisopropylamine

diisopropylamine

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas refluxed for 3 hours under a nitrogen atmosphere
2. 2
   Sonstigewas removed from the mixture by distillation under reduced pressure
3. 3
   Sonstigeprecipitates
4. 4
   Filtrationwere collected by filtration
5. 5
   Sonstigedried under reduced pressure

Vorschrift

A mixture of 2,5-dibromopyridine (15.0 g, 63.9 mmol), N-acetyl-propargylamine (15.51 g), and PdCl2(PPh3)2 (453 mg) in diisopropylamine (510 mL) was refluxed for 3 hours under a nitrogen atmosphere. To the mixture was added water (200 ml) and diisopropylamine was removed from the mixture by distillation under reduced pressure. The resulting suspension was aged at ambient temperature for 1 hour, and precipitates were collected by filtration and dried under reduced pressure to provide 2-1 (14.0 g).

Quelle