Reaktion #77842

ord-1db6a852ee124d41bdfef8f19c0efa39

Reaktionsgleichung

CN1[C@H]2CC[C@@H]1[C@@H](c1ncc(-c3ccccc3)s1)[C@@H](c1ccc(Cl)cc1)C2.c1cscn1
thiazole
CN1[C@H]2CC[C@@H]1[C@@H](c1ncc(-c3ccccc3)s1)[C@@H](c1ccc(Cl)cc1)C2.c1cscn1
thiazole RTI-219
→
CN1[C@H]2CC[C@@H]1[C@@H](c1ncc(-c3ccccc3)s1)[C@@H](c1ccc(Cl)cc1)C2.Cl
3β-(4-Chlorophenyl)-2β-(5-phenylthiazol-2-yl)-tropane Hydrochloride

Edukte

CN1[C@H]2CC[C@@H]1[C@@H](c1ncc(-c3ccccc3)s1)[C@@H](c1ccc(Cl)cc1)C2.c1cscn1
thiazole
CN1[C@H]2CC[C@@H]1[C@@H](c1ncc(-c3ccccc3)s1)[C@@H](c1ccc(Cl)cc1)C2.c1cscn1
thiazole RTI-219
—
hydrochloride salt

Reagenzien

Keine

Lösungsmittel

CO
CH3OH

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The thiazole was converted into hydrochloride salt: 1H NMR (MeOD) 1.99 (m, 1H), 2.51 (m, 5H), 2.93 (s, 3H), 3.79 (m, 2 H), 4.15 (m, 1H), 4.28 (m, 1H), 7.02 (d, J=8.5 Hz, 2H) 7.21 (d, J=8.5 Hz, 2H), 7.39 (m, 5H), 8.06 (s, 1H); mp 228-230° C.; Anal calcd for C23H24CIN2S.H2O; C=61.47, H=5.83, N=6.23, S=7.13, Cl=15.78; found C=61.61, H=5.76, N=6.20, S=7.51, Cl=15.84; [α]D+27.43° (c=0.11, CH3OH)

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06706880B2uspto-grants-2004_03