Reaktion #77808

Reaktionsgleichung

5-amino-2-methoxy-N-(4-trifluoromethylbenzyl)benzamide

hydrobromic acid

sodium nitrite

acrylamide

→

5-(2-bromo-2-carbamoylethyl)-2-methoxy-N-(4-trifluoromethylbenzyl)benzamide

Lösungsmittel

acetone

methanol

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturunder cooling with ice
2. 2
   workup.STIRRINGwas stirred further for 2 hours at 30° C
3. 3
   workup.DISTILLATIONSolvent was distilled off under reduced pressure, and 25% aqueous ammonia
4. 4
   workup.ADDITIONwas added to the residue, which
5. 5
   Extraktionwas extracted with ethyl acetate
6. 6
   WaschenThe organic layer was washed with water and saturated brine in sequence
7. 7
   Trocknendried over anhydrous sodium sulfate
8. 8
   workup.DISTILLATIONSolvent was distilled off under reduced pressure
9. 9
   Sonstigethe residue obtained
10. 10
    Sonstigewas crystallized from hexane
11. 11
    Filtrationethyl acetate=1:1, and then the crystals were collected by filtration

Vorschrift

To a solution of 2.26 g of 5-amino-2-methoxy-N-(4-trifluoromethylbenzyl)benzamide in 27 ml of acetone and 11 ml of methanol were added 5.6 ml of 47% solution of hydrobromic acid, 540 mg of sodium nitrite and 2 ml of water under cooling with ice, and the mixture was stirred for 10 minutes. To the reaction mixture were added 3.00 g of acrylamide, and, after heated to 30° C., 135 mg of cupric oxide were added little by little, and the mixture was stirred further for 2 hours at 30° C. Solvent was distilled off under reduced pressure, and 25% aqueous ammonia was added to the residue, which was extracted with ethyl acetate. The organic layer was washed with water and saturated brine in sequence and dried over anhydrous sodium sulfate. Solvent was distilled off under reduced pressure, the residue obtained was crystallized from hexane:ethyl acetate=1:1, and then the crystals were collected by filtration to obtain 1.55 g of 5-(2-bromo-2-carbamoylethyl)-2-methoxy-N-(4-trifluoromethylbenzyl)benzamide as colorless crystals.

Quelle