Reaktion #7779

Reaktionsgleichung

2-(3-bromo-4-methylphenyl)-1,3-benzoxazole

n-bromosuccinimide

benzoyl peroxide

→

2-[3-bromo-4-(bromomethyl)phenyl]-1,3-benzoxazole

Lösungsmittel

carbon tetrachloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas refluxed for 3 h
2. 2
   FiltrationThe white precipitate was filtered
3. 3
   Sonstigethe filtrate was evaporated to dryness
4. 4
   SonstigeThe resulting solid was purified by flash chromatography on silica gel eluting with EtOAc:hexane (1:5)

Vorschrift

A mixture of 2-(3-bromo-4-methylphenyl)-1,3-benzoxazole (240 mg, 0.83 mmol), n-bromosuccinimide (180 mg, 0.99 mmol), and benzoyl peroxide (10 mg, 0.041 mmol) in carbon tetrachloride (15 mL) was refluxed for 3 h. The white precipitate was filtered and the filtrate was evaporated to dryness. The resulting solid was purified by flash chromatography on silica gel eluting with EtOAc:hexane (1:5) to afford 2-[3-bromo-4-(bromomethyl)phenyl]-1,3-benzoxazole as a yellow solid.

Quelle