Reaktion #77777

ord-a30536b2cdbc41fa876b13256e605af7

Reaktionsgleichung

CC(C)(C)OC(=O)N1CCc2cc(OCCCCBr)ccc21
5-(4-Bromo-butoxy)-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester
CCNCCOC
methoxyethyl-ethylamine
→
COCCN(C)CCCCOc1ccc2c(c1)CCN2C(=O)OC(C)(C)C
5-{4-[(2-Methoxy-ethyl)-methyl-amino]-butoxy}-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester

Edukte

CC(C)(C)OC(=O)N1CCc2cc(OCCCCBr)ccc21
5-(4-Bromo-butoxy)-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester
CCNCCOC
methoxyethyl-ethylamine

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

In analogy to example 7.2, 5-(4-Bromo-butoxy)-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester and methoxyethyl-ethylamine were converted to yield 5-{4-[(2-Methoxy-ethyl)-methyl-amino]-butoxy}-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester as colorless oil, MS: 379 (MH+).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06706751B2uspto-grants-2004_03