Reaktion #77697

Reaktionsgleichung

2-amino-5-bromobenzonitrile

phenylboronic acid

potassium carbonate

→

desired compound

Ausbeute 91.6%

2-Amino-4-phenylbenzonitrile

Ausbeute 91.6%

Lösungsmittel

dimethoxyethane water

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas heated
2. 2
   Temperaturat reflux for 4 hours
3. 3
   Extraktionextracted with ethyl acetate
4. 4
   SonstigeThe organic phase was dried
5. 5
   Sonstigesolvent evaporated

Vorschrift

A mixture of 2-amino-5-bromobenzonitrile (1.0 g, 5 mmol), phenylboronic acid (0.92 g, 7.5 mmol), tetrakis(triphenylphosphine)palladium (50 mg) and potassium carbonate (3.5 g, 25 mmol) in dimethoxyethane/water 2:1 (60 mL) was heated at reflux for 4 hours. After cooling to room temperature the reaction was diluted with water and extracted with ethyl acetate. The organic phase was dried and solvent evaporated. Trituation with petroleum ether gave 0.89 g of the desired compound.

Quelle