Reaktion #77620

Reaktionsgleichung

1-(4-bromo-2-thienyl)-1-propanone

(3-carboxypropyl)triphenylphosphonium bromide

potassium tert-butoxide

→

desired product

(E)-5-(4-Bromo-2-thienyl)-4-heptenoic Acid

Reaktionsbedingungen

Vorschrift

In a manner similar to that of Example 6(i), by reaction of 16 g (73 mmol) of 1-(4-bromo-2-thienyl)-1-propanone with 47 g (109 mmol) of (3-carboxypropyl)triphenylphosphonium bromide and 24.6 g (219 mmol) of potassium tert-butoxide, the desired product is obtained in the form of an orange-coloured solid (m=16.7 g; Y=80%).

Quelle