Reaktion #77607

Reaktionsgleichung

5-(2-ethyl-[1,3]dioxolan-2-yl)-2-thienylmethyl methanesulphonate

dimethyl 4-hydroxyphthalate

potassium carbonate

sodium iodide

→

Dimethyl 4-[5-(2-Ethyl-[1,3]dioxolan-2-yl)-2-thienylmethoxy]phthalate

Lösungsmittel

2-butanone

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe mixture is refluxed for 12 hours
2. 2
   Temperaturcooled
3. 3
   Filtrationfiltered
4. 4
   EinengenThe filtrate is concentrated under reduced pressure
5. 5
   Sonstigepurified by chromatography on a column of silica
6. 6
   SonstigeA yellow oil is obtained (m=12.70 g; Y=73%)

Vorschrift

9.25 g (43.2 mmol) of 5-(2-ethyl-[1,3]dioxolan-2-yl)-2-thienylmethyl methanesulphonate are dissolved in 100 mL of 2-butanone, and 9.07 g (43.2 mmol) of dimethyl 4-hydroxyphthalate (prepared in Example 1(b)), 6 g of potassium carbonate (43.2 mmol) and 20 mg of sodium iodide are added. The mixture is refluxed for 12 hours, cooled and filtered. The filtrate is concentrated under reduced pressure and then purified by chromatography on a column of silica. A yellow oil is obtained (m=12.70 g; Y=73%).

Quelle