Reaktion #77574

Reaktionsgleichung

sodium hydroxide

hydrochloric acid

diisobutylaluminum hydride

toluene

Methanol

1,4-bis[5-[3,5-bis(methoxycarbonyl)phenyl]-2-pyridyl]hexahydro-1,4-diazepine

→

title compound

Ausbeute 53.0%

1,4-Bis[5-[3,5-bis(hydroxymethyl)phenyl]-2-pyridyl]hexahydro-1,4-diazepine

Ausbeute 53.0%

Lösungsmittel

brine

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe bath was removed
2. 2
   workup.STIRRINGThe mixture was stirred at room temperature for 1 hour
3. 3
   ExtraktionThe resulting mixture was extracted with chloroform
4. 4
   Trocknenthe organic layer was dried over anhydrous sodium sulfate
5. 5
   Einengenconcentrated under reduced pressure
6. 6
   SonstigeThe residue was purified by preparative thin-layer chromatography on silica gel

Vorschrift

Under nitrogen, a solution of 1,4-bis[5-[3,5-bis(methoxycarbonyl)phenyl]-2-pyridyl]hexahydro-1,4-diazepine (17.0 mg, 0.0266 mmol), which had been synthesized in Example 20, in anhydrous tetrahydrofuran (1.0 mL) was cooled to −20° C. To the resulting solution was added a 1.0 M solution of diisobutylaluminum hydride in toluene (0.40 mL, 0.40 mmol), and the resulting mixture was stirred for 1 hour. Methanol (0.2 mL, 4.9 mmol) was added to the mixture, and the bath was removed, then 0.50 M hydrochloric acid (1.0 mL, 0.50 mmol) was added. The mixture was stirred at room temperature for 1 hour, and a 1.0 M aqueous sodium hydroxide (1.0 mL, 1.0 mmol) and brine were added. The resulting mixture was extracted with chloroform, and the organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by preparative thin-layer chromatography on silica gel to yield the title compound as a colorless amorphous powder (7.4 mg, yield: 53%).

Quelle