Reaktion #77552

ord-597fe6403f9644519bd7f2c81d9ccbbb

Reaktionsgleichung

Nc1cc[nH]n1
compound 3
Nc1cc[nH]n1
3-aminopyrazole
CC1=C(C(=O)OC(C)(C)C)C(C(C)C)n2nccc2N1
compound 4
CC1=C(C(=O)OC(C)(C)C)C(C(C)C)n2nccc2N1
4,7-Dihydro-5-methyl-7-(1-methylethyl)pyrazolo[1,5-a]pyrimidine-6-carboxylic acid 1,1-dimethylethyl ester
→
CC1=C(C(=O)N2CCN(c3ccccc3)CC2)Cn2nccc2N1
title compound
CC1=C(C(=O)N2CCN(c3ccccc3)CC2)Cn2nccc2N1
1-[(4,7-Dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)carbonyl]-4-phenylpiperazine

Edukte

Nc1cc[nH]n1
compound 3
Nc1cc[nH]n1
3-aminopyrazole
CC1=C(C(=O)OC(C)(C)C)C(C(C)C)n2nccc2N1
compound 4
CC1=C(C(=O)OC(C)(C)C)C(C(C)C)n2nccc2N1
4,7-Dihydro-5-methyl-7-(1-methylethyl)pyrazolo[1,5-a]pyrimidine-6-carboxylic acid 1,1-dimethylethyl ester

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Condensation of compound 3 and compound 4 as described in Example 18, Method 2 Step C provided the title compound. Reverse Phase LC/MS: YMC S5 ODS 4.6×50 mm Ballistic column, UV detection at 220λ, 4 min. gradient 0-100% Solvent B/A (Solvent A: 10% MeOH/H2O with 0.1% TFA, Solvent B: 90% MeOH/H2O with 0.1% TFA), 4 mL/min. Rt=1.96 min, (87% pure). (M+H: 323).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06706720B2uspto-grants-2004_03