Reaktion #77477

Reaktionsgleichung

sodium methoxide

(±)-7-(2-chloro-5-fluorophenyl)-5-guanidinoimino-4-methyl-5,6,7,8-tetrahydroquinoline hydrochloride

→

(±)-7-(2-chloro-5-fluorophenyl)-5-guanidinoimino-4-methyl-5,6,7,8-tetrahydroquinoline

Ausbeute 89.2%

Lösungsmittel

methanol

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Einengenwas concentrated under reduced pressure
2. 2
   Waschenthe result was washed with water
3. 3
   Sonstigedried

Vorschrift

(±)-7-(2-chloro-5-fluorophenyl)-5-guanidinoimino-4-methyl-5,6,7,8-tetrahydroquinoline hydrochloride (8.8 g) was suspended in methanol (100 ml) and treated dropwise with a 28% solution of sodium methoxide in methanol (8.9 g) The mixture was concentrated under reduced pressure, and the result was washed with water and dried to obtain (±)-7-(2-chloro-5-fluorophenyl)-5-guanidinoimino-4-methyl-5,6,7,8-tetrahydroquinoline (7.1 g).

Quelle