Reaktion #77454

ord-42fc8f3633eb4fe2a0704ca5615a18c6

Reaktionsgleichung

COCCS(N)(F)(F)(F)CCOC
bis-(2-methoxyethyl)-aminosulphur trifluoride
CN1[C@@H]2CC=C[C@@]1(OC(=O)C(O)(c1ccc(F)cc1)c1ccc(F)cc1)CC2
5d
CN1[C@@H]2CC=C[C@@]1(OC(=O)C(O)(c1ccc(F)cc1)c1ccc(F)cc1)CC2
Tropenol 4,4′-difluorobenzilate
→
CN1[C@@H]2CC=C[C@@]1(O)CC2.O=C([O-])C(F)(c1ccc(F)cc1)c1ccc(F)cc1
Tropenol 2-fluoro-2,2-bis(4-fluorophenyl)-acetate

Edukte

COCCS(N)(F)(F)(F)CCOC
bis-(2-methoxyethyl)-aminosulphur trifluoride
CN1[C@@H]2CC=C[C@@]1(OC(=O)C(O)(c1ccc(F)cc1)c1ccc(F)cc1)CC2
5d
CN1[C@@H]2CC=C[C@@]1(OC(=O)C(O)(c1ccc(F)cc1)c1ccc(F)cc1)CC2
Tropenol 4,4′-difluorobenzilate

Reagenzien

Keine

Lösungsmittel

ClCCl
dichloromethane

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeThe product is recrystallised from acetonitrile in the form of its hydrochloride

Vorschrift

2.94 g (0.013 mol) of bis-(2-methoxyethyl)-aminosulphur trifluoride are reacted with 3.85 g (0.01 mol) of 5d analogously to Example 4, step 4.3 in 100 ml of dichloromethane. The product is recrystallised from acetonitrile in the form of its hydrochloride.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06706726B2uspto-grants-2004_03