Reaktion #77433

Reaktionsgleichung

4-(4-aminomethyl-phenoxy)-phenol

5-bromo-5-(2-ethoxy-ethyl)-pyrimidine-2,4,6-trione

dec-5-ene

PTBD

→

5-[4-(4-aminomethyl-phenoxy)-phenoxy]-5-(2-ethoxy-ethyl)-pyrimidine-2,4,6-trione

Ausbeute 18.1%

Lösungsmittel

acetonitrile

Reaktionsbedingungen

Vorschrift

Following the procedure outlined for the preparation of Example 1, 4-(4-aminomethyl-phenoxy)-phenol (0.70 g, 3.32 mmol) was reacted with 5-bromo-5-(2-ethoxy-ethyl)-pyrimidine-2,4,6-trione (0.95 g, 2.4 mmol), 1,5,7-trazabicyclo[4.4.0]dec-5-ene bound to polystyrene crosslinked with 2% DVB (PTBD, Fluka, 2.22 9) and 11 mL of acetonitrile, affording 5-[4-(4-aminomethyl-phenoxy)-phenoxy]-5-(2-ethoxy-ethyl)-pyrimidine-2,4,6-trione (0.180 g) as a colorless solid after purification by reverse phase HPLC.

Quelle