Reaktion #77389

Reaktionsgleichung

5-chlorosulfonyl-2-oxindole

4-fluorobenzylamine

pyridine

→

2-oxo-2,3-dihydro-1H-indole-5-sulfonic acid-4-fluoro-benzylamide

Ausbeute 84.0%

Lösungsmittel

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe precipitate was filtered
2. 2
   Waschenwashed with dichloromethane
3. 3
   Sonstigedried

Vorschrift

A suspension of 5-chlorosulfonyl-2-oxindole (5.0 g), 4-fluorobenzylamine (3.0 mL) and pyridine (3.5 mL) in dichloromethane (30 mL) was stirred at room temperature for 4 hours. The precipitate was filtered, washed with dichloromethane and dried to give 5.8 g (84%) of 2-oxo-2,3-dihydro-1H-indole-5-sulfonic acid-4-fluoro-benzylamide.

Quelle