Reaktion #77315

ord-fabb7311f562439b82a73e4d38dda136

Reaktionsgleichung

O=[N+]([O-])c1ccc(Cl)c(Cl)c1Cl
2,3,4-trichloro-nitro-benzene
O=C(O)C1CN(C(=O)OCc2ccccc2)CCN1
4-carbobenzyloxypiperazine-2-carboxylic acid
→
O=C(O)C1CN(C(=O)OCc2ccccc2)CCN1c1c([N+](=O)[O-])ccc(Cl)c1Cl
desired product
Ausbeute 43.6%
O=C(O)C1CN(C(=O)OCc2ccccc2)CCN1c1c([N+](=O)[O-])ccc(Cl)c1Cl
4-Carbobenzyloxy-1-(5,6-Dichloro-2-Nitrophenyl)Piperazine-2-Carboxylic Acid
Ausbeute 43.6%

Edukte

O=[N+]([O-])c1ccc(Cl)c(Cl)c1Cl
2,3,4-trichloro-nitro-benzene
O=C(O)C1CN(C(=O)OCc2ccccc2)CCN1
4-carbobenzyloxypiperazine-2-carboxylic acid

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

By the same procedure described for Example 7 A, from 0.86 g of 2,3,4-trichloro-nitro-benzene and 1.0 g of 4-carbobenzyloxypiperazine-2-carboxylic acid, there was obtained 0.75 g of the desired product as a brown oil.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06706714B2uspto-grants-2004_03