Reaktion #77303

Reaktionsgleichung

1-(2,4,5-trifluorophenyl)piperazine

(S)-8-(2-chloro-1-methylethyl)-8-azaspiro[4.5]decane-7,9-dione

→

title compound

Ausbeute 52.4%

8-{(1S)-2-[4-(2,4,5-Trifluorophenyl)piperazin-1-yl]-1-methylethyl}-8-azaspiro[4.5]decane-7,9-dione

Ausbeute 52.4%

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas heated
2. 2
   SonstigeThe residue was purified by preparative HPLC (see Example 8 for conditions)
3. 3
   Sonstigegiving (

Vorschrift

A mixture of 1-(2,4,5-trifluorophenyl)piperazine (20 mg, 0.093 mmol) and (S)-8-(2-chloro-1-methylethyl)-8-azaspiro[4.5]decane-7,9-dione (20 mg, 0.082 mmol) was heated with stirring at 160° C. for 5 hours. The residue was purified by preparative HPLC (see Example 8 for conditions), giving (after removal of the solvent) the title compound as a pale yellow oil (18.1 mg, 0.043 mmol, 52%): ESI-MS m/z 424 (MH+).

Quelle