Reaktion #77302

Reaktionsgleichung

1-(2,5-difluorophenyl)piperazine

(S)-8-(2-chloro-1-methylethyl)-8-azaspiro[4.5]decane-7,9-dione

→

title compound

Ausbeute 32.0%

8-{(1S)-2-[4-(2,5-Difluorophenyl)piperazin-1-yl]-1-methylethyl}-8-azaspiro[4.5]decane-7,9-dione

Ausbeute 32.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas heated
2. 2
   SonstigeThe residue was purified by preparative HPLC (see Example 8 for conditions)
3. 3
   Sonstigegiving (

Vorschrift

A mixture of 1-(2,5-difluorophenyl)piperazine (20 mg, 0.10 mmol) and (S)-8-(2-chloro-1-methylethyl)-8-azaspiro[4.5]decane-7,9-dione (20 mg, 0.082 mmol) was heated with stirring at 160° C. for 5 hours. The residue was purified by preparative HPLC (see Example 8 for conditions), giving (after removal of the solvent) the title compound as a pale yellow oil (10.8 mg, 0.026 mmol, 32%): ESI-MS m/z 406 (MH+).

Quelle