Reaktion #77296

Reaktionsgleichung

NaOH

2,5-difluoroaniline

bis(2-chloroethyl)amine hydrochloride

sodium carbonate

→

title compound

Ausbeute 15.5%

(2,5-Difluorophenyl)piperazine

Ausbeute 15.5%

Lösungsmittel

hexane

butanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas heated
2. 2
   Temperaturat reflux for 24 hours
3. 3
   Temperaturthe mixture was heated again
4. 4
   Temperaturat reflux
5. 5
   Temperaturthe mixture was cooled to room temperature
6. 6
   Sonstigethe resulting layers were separated
7. 7
   ExtraktionThe aqueous layer was extracted with chloroform (3×25 mL)
8. 8
   WaschenThe silica gel was further eluted with a gradient of chloroform to chloroform/methanol (4:1)
9. 9
   SonstigeThe solvent was removed from the combined fractions with Rf=0.14 [silica gel, chloroform/methanol (4:1)]

Vorschrift

A mixture of 2,5-difluoroaniline (2.58 g, 20 mmol) and bis(2-chloroethyl)amine hydrochloride (3.96 g, 22 mmol) in butanol (10 mL) was heated at reflux for 24 hours. The mixture was cooled to room temperature, sodium carbonate (2.33 g, 22 mmol) was added, and the mixture was heated again at reflux. After 2 days, the mixture was cooled to room temperature, hexane (15 mL) and 3 N NaOH (25 mL) were added, and the resulting layers were separated. The aqueous layer was extracted with chloroform (3×25 mL) and the combined organic fractions were flashed over a column of silica gel. The silica gel was further eluted with a gradient of chloroform to chloroform/methanol (4:1). The solvent was removed from the combined fractions with Rf=0.14 [silica gel, chloroform/methanol (4:1)], giving the title compound as a yellow oil (0.606 g, 3.1 mmol, 15%). ESI-MS m/z 199 (MH+).

Quelle