Reaktion #77290

Reaktionsgleichung

5-[3,6-dihydro-3-methyl-2,6-dioxo-4-(trifluoromethyl)-1(2H)-pyrimidinyl]-1,2-benzisothiazole-3-carboxaldehyde

2-(butylamino)ethanethiol

ethanol

→

title compound

Ausbeute 31.7%

3-[3-(3-Butyl-2-thiazolidinyl)-1,2-benzisothiazol-5-yl]-1-methyl-6-(trifluoromethyl)uracil

Ausbeute 31.7%

Lösungsmittel

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   Einengenconcentrated in vacuo
2. 2
   SonstigeThe residue is chromatographed on silica gel with ethyl acetate-hexanes

Vorschrift

A mixture of 5-[3,6-dihydro-3-methyl-2,6-dioxo-4-(trifluoromethyl)-1(2H)-pyrimidinyl]-1,2-benzisothiazole-3-carboxaldehyde (0.500 g, 1.41 mmol), 2-(butylamino)ethanethiol (0.250 ml, 1.69 mmol), ethanol and tetrahydrofuran is stirred overnight at room temperature and concentrated in vacuo. The residue is chromatographed on silica gel with ethyl acetate-hexanes to afford the title compound as a light yellow solid (0.210 g, 31.7%, mp 78-82° C.) which is identified by NMR spectral analysis.

Quelle