Reaktion #7728

Reaktionsgleichung

2,4-dichloropyrimidine

ethyl N-methylglycinate

triethylamine

→

Ethyl N-(4-chloro-2-pyrimidinyl)-N-methylglycinate

Lösungsmittel

dioxane

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe mixture is filtered off with suction
2. 2
   Einengenthe mother liquor is concentrated to half the original volume
3. 3
   SonstigeA solid crystallizes out, which
4. 4
   Filtrationis filtered off with suction
5. 5
   EinengenThe mother liquor is concentrated
6. 6
   Filtrationthe product is filtered off

Vorschrift

30.0 g (0.20 mol) of 2,4-dichloropyrimidine, 30.9 g (0.20 mol) of ethyl N-methylglycinate and 61.0 g (0.60 mol) of triethylamine in 200 ml of dioxane are stirred at 50° C. for 10 min. The mixture is filtered off with suction and the mother liquor is concentrated to half the original volume. A solid crystallizes out, which is filtered off with suction. The mother liquor is concentrated, the residue is stirred with petroleum ether and the product is filtered off.

Quelle