Reaktion #77254

Reaktionsgleichung

4-amino-5-fluoro-2-(3-methylpicolinoyl)phenyl thiocyanate

ammonium hydroxide

→

title compound

Ausbeute 66.6%

5-Amino-6-fluoro-3-(3-methyl-2-pyridyl)-1,2-benzisothiazole

Ausbeute 66.6%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe methanol is removed in vacuo
2. 2
   Filtrationthe resultant mixture is filtered

Vorschrift

A mixture of 4-amino-5-fluoro-2-(3-methylpicolinoyl)phenyl thiocyanate(3.06 g, 0.0112 mole), concentrated ammonium hydroxide (300 ml) and methanol (300 ml) is stirred overnight at room temperature. The methanol is removed in vacuo and the resultant mixture is filtered to afford the title compound as a green solid (1.93 g, 66.6%) which is identified by NMR spectral analysis.

Quelle