Reaktion #77247

Reaktionsgleichung

3-[3-[3-(bromomethyl)-2-thienyl]-1,2-benzisothiazol-5-yl]-1-methyl-6-(trifluoromethyl)uracil

methylene chloride

methanol

→

title compound

Ausbeute 87.7%

3-[3-[3-(Methoxymethyl)-2-thienyl]-1,2-benzisothiazol-5-yl]-1-methyl-6-(trifluoromethyl)uracil

Ausbeute 87.7%

Reaktionsbedingungen

Aufarbeitung

1. 1
   Filtrationfiltered through a pad of diatomaceous earth with methylene chloride
2. 2
   Waschenwash
3. 3
   WaschenThe filtrate is washed with saturated sodium bicarbonate and brine
4. 4
   Trocknendried over anhydrous magnesium sulfate
5. 5
   Einengenconcentrated in vacuo to a pale yellow solid, which
6. 6
   Sonstigeis recrystallized from diethyl ether

Vorschrift

To a mixture of 3-[3-[3-(bromomethyl)-2-thienyl]-1,2-benzisothiazol-5-yl]-1-methyl-6-(trifluoromethyl)uracil(1.00 g, 1.99 mmol), methylene chloride and methanol is added silver trifluorormethanesulfonate. The resultant white suspension is stirred overnight at room temperature and filtered through a pad of diatomaceous earth with methylene chloride wash. The filtrate is washed with saturated sodium bicarbonate and brine, dried over anhydrous magnesium sulfate and concentrated in vacuo to a pale yellow solid, which is recrystallized from diethyl ether to afford the title compound (0.790 g, 87.7%, mp 131-133° C.) which is identified by NMR spectral analysis.

Quelle