Reaktion #7698

Reaktionsgleichung

(2-chloroquinazolin-4-yl)-(5-methyl-2H-pyrazol-3-yl)-amine

3-chloroaniline

K2CO3

→

[2-(3-chlorophenylamino)-quinazolin-4-yl]-(5-methyl-2H-pyrazol-3-yl)-amine

Lösungsmittel

tert-butanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenThe mixture is concentrated in vacuo
2. 2
   SonstigeThe solid that forms is collected
3. 3
   Sonstigedried under vacuum

Vorschrift

The above-prepared (2-chloroquinazolin-4-yl)-(5-methyl-2H-pyrazol-3-yl)-amine (155 mg, 0.6 mmol) and 3-chloroaniline (0.316 mL, 2.99 mmol) are refluxed in tert-butanol (3 mL) over 20 h. The mixture is concentrated in vacuo and the residue is suspended in EtOH/H2O (1 mL/3 mL). K2CO3 (83 mg, 0.6 mmol) is added and the suspension is stirred for 2 h at room temperature. The solid that forms is collected and dried under vacuum to give the product [2-(3-chlorophenylamino)-quinazolin-4-yl]-(5-methyl-2H-pyrazol-3-yl)-amine.

Quelle