Reaktion #7694

Reaktionsgleichung

chloroacetonitrile

benzylpiperazine

→

N-benzyl-N′-cyanomethylpiperazine

Lösungsmittel

THF

Et3N

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigebefore quenched with saturated aqueous NaHCO3 (100 ml)
2. 2
   ExtraktionThe aqueous phase was extracted with EtOAc (3×100 ml)
3. 3
   TrocknenThe combined organic layer was dried over MgSO4
4. 4
   Einengenconcentrated to a residue, which
5. 5
   Sonstigewas used in the further reactions without any purification

Vorschrift

An excess of chloroacetonitrile (7 ml) was added in to a solution of benzylpiperazine (2 g, 10.5 mmol) in THF (100 ml) and Et3N (10 ml). The reaction was stirred for 10 hours before quenched with saturated aqueous NaHCO3 (100 ml). The aqueous phase was extracted with EtOAc (3×100 ml). The combined organic layer was dried over MgSO4 and concentrated to a residue, which was used in the further reactions without any purification.

Quelle