Reaktion #76904

ord-0c65c93673b541c7ba572cc0ccbf9ef3

Reaktionsgleichung

COc1ccc(CC2NCCc3cc(OC)c(OC)cc32)cc1OC
1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline
O=C(Br)CBr
2-bromoacetyl bromide
Cc1ccccc1CN
2-methylbenzylamine
→
COc1ccc(CC2c3cc(OC)c(OC)cc3CCN2CC(=O)NCc2ccccc2C)cc1OC
2-[1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(2-methyl-benzyl)-acetamide

Edukte

COc1ccc(CC2NCCc3cc(OC)c(OC)cc32)cc1OC
1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline
O=C(Br)CBr
2-bromoacetyl bromide
Cc1ccccc1CN
2-methylbenzylamine

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2-methylbenzylamine

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06703392B2uspto-grants-2004_03