Reaktion #76893

ord-0a2f47d1a19f43c5b91cccb389f31b08

Reaktionsgleichung

COc1ccc(CC2NCCc3cc(OC)c(OC)cc32)cc1
1-(4-Methoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline
O=C(Br)CBr
2-bromoacetyl bromide
NC1CCCc2ccccc21
1,2,3,4-tetrahydro-1-naphthylamine
→
COc1ccc(CC2c3cc(OC)c(OC)cc3CCN2CC(=O)NC2CCCc3ccccc32)cc1
2-[1-(4-Methoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-acetamide

Edukte

COc1ccc(CC2NCCc3cc(OC)c(OC)cc32)cc1
1-(4-Methoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline
O=C(Br)CBr
2-bromoacetyl bromide
NC1CCCc2ccccc21
1,2,3,4-tetrahydro-1-naphthylamine

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

prepared by reaction of 1-(4-Methoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline and 2-bromoacetyl bromide with 1,2,3,4-tetrahydro-1-naphthylamine

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06703392B2uspto-grants-2004_03