Reaktion #76873

ord-3b46a2b4b0cc4b56a8b2662b11ae4a5b

Reaktionsgleichung

COc1ccc2c(c1)CCNC2Cc1ccc(OC)c(OC)c1
1-(3,4-dimethoxy-benzyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline
O=C(Br)CBr
2-bromoacetyl bromide
Cc1cccc(CN)c1
3-methylbenzylamine
→
COc1ccc2c(c1)CCN(CC(=O)NCc1cccc(C)c1)C2Cc1ccc(OC)c(OC)c1
2-[1-(3,4-Dimethoxy-benzyl)-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(3-methyl-benzyl)-acetamide

Edukte

COc1ccc2c(c1)CCNC2Cc1ccc(OC)c(OC)c1
1-(3,4-dimethoxy-benzyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline
O=C(Br)CBr
2-bromoacetyl bromide
Cc1cccc(CN)c1
3-methylbenzylamine

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

prepared by reaction of 1-(3,4-dimethoxy-benzyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 3-methylbenzylamine

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06703392B2uspto-grants-2004_03