Reaktion #76733

Reaktionsgleichung

5-[4-Ethoxy-1-(2-trimethylsilanyl-ethoxymethyl)-1H-indol-6-ylmethyl]-pyrimidine-2,4-diamine

guanidine hydrochloride

potassium tert-butylate

potassium tert-butylate

4-ethoxy-1-(2-trimethylsilanyl-ethoxymethyl)-1H-indole-6-carbaldehyde

3-anilinopropionitrile

→

title compound

Ausbeute 62.0%

5-(4-Ethoxy-1H-indol-6-ylmethyl)-pyrimidine-2,4-diamine

Ausbeute 62.0%

Lösungsmittel

water

ethanol

tert-butanol

methyl sulfoxide

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe suspension formed
2. 2
   FiltrationThe precipitate was collected by filtration
3. 3
   Sonstigedried
4. 4
   Temperaturthe reaction mixture was refluxed for 16 h
5. 5
   workup.DISTILLATIONmost of the solvent was distilled off
6. 6
   workup.ADDITIONether (50 mL) was added
7. 7
   SonstigeInsoluble material was removed by filtration
8. 8
   Waschenthe filtrate was washed with water
9. 9
   Trocknendried (MgSO4)
10. 10
    Sonstigeevaporated
11. 11
    WaschenThe residue was washed with diethyl ether/n-hexane 4:3 (70 mL)

Vorschrift

5-[4-Ethoxy-1-(2-trimethylsilanyl-ethoxymethyl)-1H-indol-6-ylmethyl]-pyrimidine-2,4-diamine. A warm solution of potassium tert-butylate (900 mg, 8.02 mmol) in tert-butanol (7.5 mL) was added at room temperature to a solution of 4-ethoxy-1-(2-trimethylsilanyl-ethoxymethyl)-1H-indole-6-carbaldehyde (2.14 g, 6.69 mmol) and 3-anilinopropionitrile (1.08 g, 7.36 mmol) in methyl sulfoxide (25 mL). After 90 min the solution was treated with water and the suspension formed was stirred for 2 h. The precipitate was collected by filtration and dried. This material was added to a suspension of guanidine hydrochloride (1.90 g, 19.9 mmol) and potassium tert-butylate (2.23 g, 19.9 mmol) in ethanol (100 mL), and the reaction mixture was refluxed for 16 h, then most of the solvent was distilled off, and ether (50 mL) was added. Insoluble material was removed by filtration, the filtrate was washed with water, dried (MgSO4), and evaporated. The residue was washed with diethyl ether/n-hexane 4:3 (70 mL) to afford the title compound (1.71 g, 62%). Light brown solid.

Quelle