Reaktion #76661

Reaktionsgleichung

THF

1,4-dibromo-2,5-Difluorobenzene

tributyl-(1-ethoxyvinyl)tin

→

1-(4-acetyl-2,5-difluorophenyl)ethan-1-one

Ausbeute 100.0%

Reaktionsbedingungen

Vorschrift

1,4-dibromo-2,5-Difluorobenzene (2.5 g, 9.2 mmol), dichlorobis(triphenylphosphine) palladium (II) (0.645 g, 0.92 mmol), tributyl-(1-ethoxyvinyl)tin (10 g, 27.7 mmol), and THF (50 mL) were combined in a manner analogous to the procedure described in example 14 to provide the intermediate title compound, 1-(4-acetyl-2,5-difluorophenyl)ethan-1-one, (1.8 g, 100%) as a white crystal. Electron spray M.S. 197.9 (M*−H).

Quelle