Reaktion #76562

Reaktionsgleichung

ethyl 7-fluoro-4-hydroxy-3-quinolinecarboxylate

→

7-fluoro-4-hydroxy-3-quinolinecarboxylic acid

Ausbeute 92.2%

Lösungsmittel

sodium hydroxide

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas heated
2. 2
   Temperaturat reflux for 3 hours during which time a solution
3. 3
   Sonstigewas obtained
4. 4
   Filtrationit was filtered
5. 5
   Filtrationthrough filter paper under vacuum
6. 6
   SonstigeThe resulting precipitate was collected
7. 7
   Waschenwashed with water
8. 8
   Sonstigedried

Vorschrift

A suspension of ethyl 7-fluoro-4-hydroxy-3-quinolinecarboxylate (65 g, 0.28 mol) in 10% sodium hydroxide (250 mL) was heated at reflux for 3 hours during which time a solution was obtained. The reaction mixture was allowed to cool to ambient temperature and then it was filtered through filter paper under vacuum. The filtrate was acidified with concentrated hydrochloric acid. The resulting precipitate was collected, washed with water and then dried to provide 53.5 g of 7-fluoro-4-hydroxy-3-quinolinecarboxylic acid as a white solid.

Quelle