Reaktion #76517

Reaktionsgleichung

product

[(1,2,3,4-Tetrahydro-6-nitro-5-quinolinyl)amino]oxo-acetic acid ethyl ester

methyl iodide

cesium carbonate

→

[Methyl(1,2,3,4-tetrahydro-6-nitro-5-quinolinyl)-amino]oxo-acetic acid ethyl ester

Ausbeute 93.0%

Lösungsmittel

acetonitrile

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe inorganic salts were removed by filtration
2. 2
   Sonstigethe filtrate evaporated
3. 3
   workup.DISSOLUTIONThe residue was dissolved in methylene chloride
4. 4
   Filtrationfiltered
5. 5
   Sonstigeevaporated
6. 6
   SonstigeThe product was then used without further purification (0.86 g, 93% yield)

Vorschrift

A mixture of the product from Example 87 (0.87 g, 3 mmol), methyl iodide (0.51 g, 3.6 mmol) and cesium carbonate (1.17 g, 3.6 mmol) in 15 mL of acetonitrile was stirred at room temperature for 2 hours. The inorganic salts were removed by filtration and the filtrate evaporated. The residue was dissolved in methylene chloride, filtered and evaporated. The product was then used without further purification (0.86 g, 93% yield).

Quelle