Reaktion #76500

Reaktionsgleichung

product

5-Bromo-1,2,3,4-tetrahydro-2-methyl-7-nitro-8-isoquinolinamine

→

5-Bromo-1,2,3,4-tetrahydro-2-methyl-7,8-isoquinolinediamine

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe reaction vessel was purged with H2
2. 2
   Sonstigethe catalyst was removed by filtration
3. 3
   Sonstigethe filtrate evaporated
4. 4
   Sonstigeto give a tan oil
5. 5
   SonstigeThe product was used without further purification

Vorschrift

A solution of the product from Example 60 (1.02 g, 3.49 mmol) in 50 mL THF was treated with Raney nickel (prewashed with acetone followed by THF), and the reaction vessel was purged with H2. After stirring for 2.5 hours, the catalyst was removed by filtration and the filtrate evaporated to give a tan oil. The product was used without further purification.

Quelle