Reaktion #7646

ord-3515f6f04b2e4e65bb53076e6c2d4d2c

Reaktionsgleichung

CCC(N)c1nnc(-c2ccc(C)c3ccccc23)[nH]c1=O
6-(1-aminopropyl)-3-(4-methyl-1-naphthyl)-1,2,4-triazin-5(4H)-one
O=C(Cl)C1CCCC1
cyclopentanecarbonyl chloride
→
CCC(NC(=O)C1CCCC1)c1nnc(-c2ccc(C)c3ccccc23)[nH]c1=O
N-{1-[3-(4-Methyl-1-naphthyl)-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl]propyl}cyclopentanecarboxamide

Edukte

CCC(N)c1nnc(-c2ccc(C)c3ccccc23)[nH]c1=O
6-(1-aminopropyl)-3-(4-methyl-1-naphthyl)-1,2,4-triazin-5(4H)-one
O=C(Cl)C1CCCC1
cyclopentanecarbonyl chloride

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeThe crude product is used in the next step without further purification

Vorschrift

In analogy to the procedure for Example 36A, 600 mg (2.04 mmol) 6-(1-aminopropyl)-3-(4-methyl-1-naphthyl)-1,2,4-triazin-5(4H)-one, 270 mg (2.04 mmol) cyclopentanecarbonyl chloride and proportionate amounts of the other reagents are used. The crude product is used in the next step without further purification.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07087605B2uspto-grants-2006_08