Reaktion #76424

Reaktionsgleichung

Hydrogen chloride

(4-hydroxyphenyl) acetic acid

methanol

→

methyl(4-hydroxyphenyl)acetate

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeAn exotherm resulted in the solution
2. 2
   Temperaturrefluxing for about 10 minutes
3. 3
   Sonstigethe solvent was evaporated in vacuo

Vorschrift

Hydrogen chloride was bubbled through a solution of (4-hydroxyphenyl) acetic acid (25 g, 0.16 mole) in methanol (100 ml) at room temperature. An exotherm resulted in the solution refluxing for about 10 minutes. The mixture was allowed to cool to room temperature and the solvent was evaporated in vacuo to afford methyl(4-hydroxyphenyl)acetate as a yellow oil (27.5 g) which crystallised on seeding, m.p. 46-52° C.

Quelle