Reaktion #76376

Reaktionsgleichung

6-bromo-naphthalene-2-ol

benzyl bromide

→

2-Benzyloxy-6-bromo-naphthalene

Lösungsmittel

DMF

cesium carbonate

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigequenched with water
2. 2
   Extraktionextracted with ethyl acetate:hexane (1:1)
3. 3
   Waschenwashed with brine, over MgSO4
4. 4
   Einengenconcentrated in vacuo

Vorschrift

To the commercially available 6-bromo-naphthalene-2-ol (1) (1 equi.) and benzyl bromide (2) (1 equi.) in DMF (3mL/mmole), cesium carbonate (1.25 equi.) was added at room temperature. The reaction mixture was stirred at that temperature for 24 h, quenched with water, extracted with ethyl acetate:hexane (1:1), washed with brine, over MgSO4, and concentrated in vacuo.

Quelle