Reaktion #76366

Reaktionsgleichung

Isobutene

2-bromo-2-methylpropanoic acid

trifluoroacetic acid

→

tert-Butyl 2-bromo-2-methylpropanoate

Lösungsmittel

CH2Cl2

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeis consumed
2. 2
   SonstigeThe volatile components are evaporated in vacuo
3. 3
   Filtrationthe residue is filtered through a pad of neutral alumina using 50% ether/hexane
4. 4
   EinengenThe filtrate is concentrated in vacuo
5. 5
   Sonstigeused without further purification

Vorschrift

Isobutene is condensed into a solution of 2-bromo-2-methylpropanoic acid (10 mmol) and trifluoroacetic acid (1 mmol) in 100 mL of CH2Cl2 until the starting material is consumed, as observed by TLC. The volatile components are evaporated in vacuo, and the residue is filtered through a pad of neutral alumina using 50% ether/hexane. The filtrate is concentrated in vacuo and used without further purification.

Quelle