Reaktion #76364

Reaktionsgleichung

HCl

1,3-propanediol

tert-butyldimethylchlorosilane

imidazole

→

product

3-(tert-Butyldimethylsiloxy)-1-propanol

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionextracted with ether (3×100 mL)
2. 2
   WaschenThe organic phases were washed with brine (100 mL)
3. 3
   Trocknendried over anhydrous MgSO4
4. 4
   Einengenconcentrated in vacuo
5. 5
   SonstigeThe mixture was purified by flash chromatography

Vorschrift

A mixture of 1,3-propanediol (10 mmol), tert-butyldimethylchlorosilane (11 mmol), and imidazole (22 mmol) dissolved in 5 mL of DMF was stirred at room temperature for 16 hours. The mixture was poured into 0.1 M HCl (100 mL) and extracted with ether (3×100 mL). The organic phases were washed with brine (100 mL), dried over anhydrous MgSO4, and concentrated in vacuo. The mixture was purified by flash chromatography to give the product as a colorless oil.

Quelle