Reaktion #76363

Reaktionsgleichung

bromine

3,4,5-trimethoxybenzoic acid

→

product

2-Bromo-3,4,5-trimethoxybenzoic Acid

Lösungsmittel

acetic acid

acetic acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturcooled by an ice water bath
2. 2
   FiltrationThe resulting solid is collected by filtration
3. 3
   Trocknendried over P2O5 in vacuo
4. 4
   Sonstigerecrystallized from Et2O

Vorschrift

A solution of bromine (100 mmol) in 100 mL of acetic acid is added dropwise to a solution of 3,4,5-trimethoxybenzoic acid (100 mmol) in 100 mL of acetic acid cooled by an ice water bath. After the red color of the resulting mixture is discharged, the mixture is poured onto 500 g of crushed ice. The resulting solid is collected by filtration, dried over P2O5 in vacuo, and recrystallized from Et2O to give the product as a pale yellow solid.

Quelle