Reaktion #7634

Reaktionsgleichung

1-cyanonaphthalene

ammonium chloride

trimethylaluminium

→

1-Naphthalenecarboximidamide hydrochloride

Lösungsmittel

methylene chloride

hexane

toluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGthe mixture is stirred at 80° C. bath temperature over night
2. 2
   TemperaturThe mixture is cooled
3. 3
   FiltrationAfter filtration
4. 4
   Waschenthe solid is washed with methanol for several times
5. 5
   Sonstigethe solution is evaporated to dryness in vacuo
6. 6
   Waschenthe residue washed with methanol
7. 7
   workup.STIRRINGstirred in a mixture of methylene chloride containing 10% methanol

Vorschrift

14 g (261 mmol, 2 equiv.) ammonium chloride are suspended in 150 ml of dry toluene under an argon athmosphere, and the mixture is cooled to 0° C. 130 ml (260 mmol, 2 equiv.) of a 2M solution of trimethylaluminium in hexane are added dropwise, and the reaction mixture is stirred at room temperature until no more evolution of gas is observed. After addition of 20 g (130 mmol, 1 equiv.) 1-cyanonaphthalene, the mixture is stirred at 80° C. bath temperature over night. The mixture is cooled and poured into a slurry of silica in methylene chloride. After filtration, the solid is washed with methanol for several times, the solution is evaporated to dryness in vacuo and the residue washed with methanol. The combined filtrates are pooled and stirred in a mixture of methylene chloride containing 10% methanol.

Quelle