Reaktion #7624
ord-ae6a67ef2da04b86bbc2bf27489624ee
Reaktionsgleichung
acetylchloride
2-aminothiazole
cyclohexylisonitrile
pyridine-2-carbaldehyde
→
7-acetyl-5-cyclohexylamino-6-pyridin-2-yl-imidazo[2,1-b]thiazol-7-ium chloride
Reagenzien
Keine
Lösungsmittel
Reaktionsbedingungen
Detaillierte Bedingungen
See reaction.notes.procedure_details.
Vorschrift
Example 22 was carried out in accordance with the general directions for synthesis in process step a) from 1.0 ml (0.1 mmol) 2-aminothiazole (0.1 M, DCM), 0.575 ml (0.115 mmol) cyclohexylisonitrile solution (0.2 M, DCM), 0.500 ml (0.15 mmol) pyridine-2-carbaldehyde solution (0.3 M, DCM) and 10 μl perchloric acid (w=20%) and in process step c) and d) by reacting the resultant reaction product with 0.4 mmol acetylchloride.