Reaktion #76210

Reaktionsgleichung

2-bromo-4′-trifluoromethylacetophenone

sodium formate

→

title compound

Ausbeute 80.1%

2-Hydroxy-4′-trifluoromethylacetophenone

Ausbeute 80.1%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas heated
2. 2
   Temperaturunder reflux
3. 3
   EinengenThe reaction mixture was concentrated
4. 4
   workup.ADDITIONpoured into water (500 mL)
5. 5
   FiltrationThe precipitated solid was collected by filtration
6. 6
   Waschenwashed with water
7. 7
   Sonstigeair-dried

Vorschrift

A mixture of 2-bromo-4′-trifluoromethylacetophenone (40.0 g), sodium formate (40.0 g) and methanol (200 mL) was heated under reflux and stirred for 6 h. The reaction mixture was concentrated and poured into water (500 mL). The precipitated solid was collected by filtration, washed with water and air-dried to give the title compound as crystals (24.5 g, 80%). melting point: 112-114° C.

Quelle