Reaktion #76196

Reaktionsgleichung

Carvedilol

→

Carvedilol

III

2-(2-Methoxyphenoxy)ethylamine

Lösungsmittel

Hexane IPA

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturby heating the mixture
2. 2
   Sonstigeto sit at room temperature
3. 3
   workup.STIRRINGwithout stirring for about 15 h
4. 4
   Filtrationthe resulting crystals were filtered through a buchner funnel
5. 5
   Sonstigedried in a desiccator (connected to air pump) at room temperature until constant weight

Vorschrift

Carvedilol (4 g) was dissolved in 180 ml, Hexane/IPA in a ratio 1:1 by heating the mixture under stirring at 55° C. water bath. The solution was allowed to sit at room temperature without stirring for about 15 h, then the resulting crystals were filtered through a buchner funnel and dried in a desiccator (connected to air pump) at room temperature until constant weight to yield Carvedilol Form III.

Quelle