Reaktion #7609

Reaktionsgleichung

acetylchloride

2-amino-3-benzyloxypyridine

cyclohexylisonitrile

acetaldehyde

→

1-acetyl-8-benzyloxy-3-cyclohexylamino-2-methyl-imidazo[1,2-a]pyridin-1-ium chloride

Lösungsmittel

perchloric acid

Reaktionsbedingungen

Vorschrift

Example 7 was carried out in accordance with the general directions for synthesis in process step a) from 1.0 ml (0.1 mmol) 2-amino-3-benzyloxypyridine (0.1 M, DCM), 0.575 ml (0.115 mmol) cyclohexylisonitrile solution (0.2 M, DCM), 0.500 ml (0.15 mmol) acetaldehyde solution (0.3 M, DCM) and 10 μl perchloric acid (w=20%) and in process step c) and d) by reacting the resultant reaction product with 0.4 mmol acetylchloride.

Quelle