Reaktion #76056

Reaktionsgleichung

tert-butyl N-[(4RS)-4-(p-toluenesulfonyl-oxymethyl)-4,5-dihydro-2-thiazolyl]carbamate

4-mercaptopyridine

potassium carbonate

→

tert-butyl N-[(4RS)-4-(4-pyridylsulphanylmethyl)-4,5-dihydro-2-thiazolyl]carbamate

Ausbeute 28.2%

Lösungsmittel

acetonitrile

ethyl acetate

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturis heated until the reagent
2. 2
   workup.DISSOLUTIONhas dissolved
3. 3
   workup.ADDITIONare added
4. 4
   workup.STIRRINGAfter stirring for 48 hours at a temperature in the region of 20° C.
5. 5
   Filtrationthe reaction mixture is filtered
6. 6
   EinengenThe filtrate is concentrated under reduced pressure (1 kPa) at a temperature in the region of 50° C
7. 7
   SonstigeThe residue obtained
8. 8
   Sonstigewater and the phases are separated after settling
9. 9
   WaschenThe organic phase is washed with sodium chloride solution
10. 10
    Trocknendried over magnesium sulfate
11. 11
    Sonstigechromatographed on a column of alumina
12. 12
    Wascheneluting with successive mixtures of ethyl acetate/cyclohexane (50/50 by volume)
13. 13
    workup.ADDITIONThe fractions containing the expected product
14. 14
    Sonstigeare purified by chromatography on a column of silica gel
15. 15
    Wascheneluting with ethyl acetate
16. 16
    workup.ADDITIONThe fractions containing the expected product
17. 17
    Einengenconcentrated under the above conditions

Vorschrift

a suspension of 1.5 g of tert-butyl N-[(4RS)-4-(p-toluenesulfonyl-oxymethyl)-4,5-dihydro-2-thiazolyl]carbamate in 50 cm3 of acetonitrile is heated until the reagent has dissolved and 0.604 g of 4-mercaptopyridine is then added with stirring. After cooling to a temperature in the region of 20° C., 1.07 g of potassium carbonate are added. After stirring for 48 hours at a temperature in the region of 20° C., the reaction mixture is filtered. The filtrate is concentrated under reduced pressure (1 kPa) at a temperature in the region of 50° C. The residue obtained is taken up in ethyl acetate and water and the phases are separated after settling has taken place. The organic phase is washed with sodium chloride solution, dried over magnesium sulfate and chromatographed on a column of alumina, eluting with successive mixtures of ethyl acetate/cyclohexane (50/50 by volume). The fractions containing the expected product are purified by chromatography on a column of silica gel, eluting with ethyl acetate. The fractions containing the expected product are combined and then concentrated under the above conditions. 0.356 g of tert-butyl N-[(4RS)-4-(4-pyridylsulphanylmethyl)-4,5-dihydro-2-thiazolyl]carbamate is obtained in the form of a yellow oil [1H NMR spectrum (300 MHz, (CD3)2SO-d6, δ in ppm): 1.42 (s: 9H); 3.09 (dd, J=11.5 and 6 Hz: 1H); 3.29 (mt: 2H); 3.40 (dd, J=11.5 and 8 Hz: 1H); 4.25 (mt: 1H); 7.35 (dd, J=5 and 1.5 Hz: 2H); 8.40 (dd, J=5 and 1.5 Hz: 2H); from 9.70 to 10.00 (broad unresolved complex: 1H)].

Quelle