Reaktion #75981

Reaktionsgleichung

N-[(1R)-2-hydroxy-1-(3-nitrobenzyl)ethyl]acetamide

hydrochloric acid

→

(2R)-2-amino-3-(3-nitrophenyl)-1-propanol hydrochloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.DISSOLUTION(dissolution)
2. 2
   EinengenThe reaction medium is concentrated under reduced pressure (2 kPa) at a temperature in the region of 40° C
3. 3
   Sonstigere-evaporated under the same conditions
4. 4
   Sonstigeto give beige-colored crystals, which
5. 5
   Waschenare washed with 3 times 20 cm3 of diethyl ether
6. 6
   Filtrationfiltered off on a sinter funnel
7. 7
   Sonstigefinally dried in a fume cupboard

Vorschrift

A suspension of 0.98 g of N-[(1R)-2-hydroxy-1-(3-nitrobenzyl)ethyl]acetamide in 10 cm3 of 6N hydrochloric acid is heated at a temperature in the region of 100° C. for 10 hours (dissolution). The reaction medium is concentrated under reduced pressure (2 kPa) at a temperature in the region of 40° C. The residue is taken up in 20 cm3 of diethyl ether and re-evaporated under the same conditions to give beige-colored crystals, which are washed with 3 times 20 cm3 of diethyl ether and then filtered off on a sinter funnel and finally dried in a fume cupboard. 0.92 g of (2R)-2-amino-3-(3-nitrophenyl)-1-propanol hydrochloride is obtained in the form of beige-colored crystals melting at 192° C. [1H NMR spectrum (250 MHz, (CD3)2SO-d6, δ in ppm): 3.06 (limiting AB: 2H); from 3.25 to 3.65 (mt: 3H); 5.45 (t, J=4.5 Hz: 1H); 7.65 (t, J=7 Hz: 1H); 7.79 (broad d, J=7 Hz: 1H); from 8.05 to 8.40 (mt: 5H)].

Quelle