Reaktion #75965

Reaktionsgleichung

4-[(2R)-2-({[(2S)-2-{[(1,1-Dimethylethyl)(dimethyl)silyl]oxy}-3-(phenyloxy)propyl]amino}methyl)-3,4-dihydro-2H-chromen-6-yl]-2-pyridinecarboxamide

4-[(2R)-2-({[(2S)-2-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-3-(phenyloxy)propyl]amino}methyl)-3,4-dihydro-2H-chromen-6-yl]-2-pyridinecarboxamide

HCl

→

4-[(2R)-2-({[(2S)-2-hydroxy-3-(phenyloxy)propyl]amino}methyl)-3,4-dihydro-2H-chromen-6-yl]-2-pyridinecarboxamide

Lösungsmittel

dioxane

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe volatile components were removed by rotary evaporation
2. 2
   Waschenthe residue was washed with dichloromethane
3. 3
   SonstigeAfter drying under vacuum
4. 4
   Sonstigethe title compound was collected as the dihydrochloride salt (8 mg, 43%)

Vorschrift

4-[(2R)-2-({[(2S)-2-{[(1,1-Dimethylethyl)(dimethyl)silyl]oxy}-3-(phenyloxy)propyl]amino}methyl)-3,4-dihydro-2H-chromen-6-yl]-2-pyridinecarboxamide (Example 93, 20 mg, 0.04 mmol) was stirred in an excess of 4M HCl in dioxane at room temperature for 30 minutes. The volatile components were removed by rotary evaporation, and the residue was washed with dichloromethane. After drying under vacuum, the title compound was collected as the dihydrochloride salt (8 mg, 43%): MS m/z 434.3 (MH+ of the free base); retention time (LC-MS)=2.02 minutes.

Quelle