Reaktion #7593

Reaktionsgleichung

benzyl bromide

2-fluoro-5-hydroxy-4-methylnitrobenzene

potassium carbonate

→

5-benzyloxy-2-fluoro-4-methylnitrobenzene

Ausbeute 80.4%

Lösungsmittel

DMF

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   ExtraktionAfter extraction with ethyl acetate
2. 2
   Waschenthe organic layer was washed with water
3. 3
   Trocknenbrine, dried (MgSO4)
4. 4
   Sonstigethe solvent evaporated
5. 5
   FiltrationThe solid was filtered off
6. 6
   Waschenwashed with hexane
7. 7
   Sonstigedried under vacuum

Vorschrift

The starting material 5-benzyloxy-2-fluoro-4-methylnitrobenzene was obtained by adding benzyl bromide (3 ml, 25 mmol) to a solution of 2-fluoro-5-hydroxy-4-methylnitrobenzene (3.92 mg, 23 mmol) in DMF (70 ml) containing potassium carbonate (9.5 g, 68 mmol). After stirring for 3 hours at 60° C. the mixture was diluted with water and adjusted to pH2. After extraction with ethyl acetate, the organic layer was washed with water and then brine, dried (MgSO4) and the solvent evaporated. The solid was filtered off, washed with hexane and dried under vacuum to give 5-benzyloxy-2-fluoro-4-methylnitrobenzene (4.83 g, 80%).

Quelle