Reaktion #7580

Reaktionsgleichung

4-chloro-7-methoxycinnoline hydrochloride

3-hydroxy-4-methylaniline

→

4-(3-hydroxy-4methylanilino)-7-methoxycinnoline

Lösungsmittel

2-pentanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas heated
2. 2
   Temperaturat reflux for 2 hours
3. 3
   TemperaturAfter cooling
4. 4
   Filtrationthe solid was filtered off
5. 5
   Waschenwashed with isopropanol, ether
6. 6
   Sonstigedried under vacuum

Vorschrift

A suspension of 4-chloro-7-methoxycinnoline hydrochloride (196 mg, 0.85 mmol) and 3-hydroxy-4-methylaniline (123 mg, 1 mmol) in 2-pentanol (5 ml) was heated at reflux for 2 hours. After cooling, the solid was filtered off, washed with isopropanol, ether and dried under vacuum to give 4-(3-hydroxy-4methylanilino)-7-methoxycinnoline as the hydrochloride salt (yellow solid, 215 mg, 80%).

Quelle