Reaktion #75783

Reaktionsgleichung

3,5-di-(1,1 dimethylethyl)-4-hydroxybenzoyl chloride

2-(4-amino-2-butyl-1H-imidazo[4,5-c][1,5]naphthyridin-1-yl)ethaneamine

→

N1-[2-(4-amino-2-butyl-1H-imidazo[4,5-c][1,5]naphthyridin-1-yl)ethyl]-3,5-di-(1,1-dimethylethyl) -4-hydroxybenzamide

Ausbeute 56.9%

Reaktionsbedingungen

Vorschrift

Using the general method of Example 92, 3,5-di-(1,1 dimethylethyl)-4-hydroxybenzoyl chloride (0.47 g, 1.7 mmol) was reacted with 2-(4-amino-2-butyl-1H-imidazo[4,5-c][1,5]naphthyridin-1-yl)ethaneamine (0.5 g, 1.7 mmol) to provide 0.5 g of N1-[2-(4-amino-2-butyl-1H-imidazo[4,5-c][1,5]naphthyridin-1-yl)ethyl]-3,5-di-(1,1-dimethylethyl) -4-hydroxybenzamide as a white powder, m.p. 248-250° C. Analysis: Calculated for C30H40N6O2: %C, 69.74; %H, 7.80; %N, 16.27. Found: %C, 69.65%H, 7.69; %N, 16.42. HRMS (EI) calcd for C30H40N6O2 (M+) 516.3212 found 516.3226

Quelle